Stem cell therapy development is an exciting area of research that promises the future treatment of many diseases. Since this area in drug development is in its infancy, there are many hurdles to overcome. The scientists at Marin Biologic are here to assist you in the many phases of your stem cell therapy development. We can culture adult or embryonic stem cells and monitor the differentiation markers for your therapy development. Please think of Marin Biologic as your stem cell research laboratory.
Microenvironment may contribute to stem cell "homing" events or differentiation. Our scientists can study microenvironments, whether generated in culture or from exogeneous tissue, and their effects on stem cell differentiation using in vitro methods. Transfecting adult or embryonic stem cells with a genetic marker to follow their "homing activities" can be performed prior to inoculation in vivo. Development of "homing" stem cells as a delivery vehicle for cancer therapy can be undertaken at Marin Biologic. Replacement therapy for hormone, cytokines and metabolic intermediates can be implemented using stem cell therapy. Insulin production is a key target for diabetes therapy using stem cells because of their "normal" detection of glucose levels and "normal" synthesis and release of insulin. Our scientists can help you to develop stems cells that synthesize your therapeutic molecule by initiating differentiation and monitoring specific production.
To implement stem cell therapy, there must be many levels of investigation ranging from the cell culture of stem cells, triggering differentiation, expanding stem cell cultures to large scale cultures for replacement therapy, determining whether immunocompatibility of embryonic stem cells is retained for transplant, down regulating HLA molecules in adult stem cells, etc. The scientists at Marin Biologic are very experienced and creative in cell biology and can bridge this field with molecular biology and biochemistry for potential cell therapy and assay development.
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